radiation nation
radiation nation

Too Much at Once? Single vs Multi-Fraction Palliative Radiation Outcomes for Spinal Metastasis

January 10, 2016

For our January #radonc journal club we will revisit palliative radiation for bone metastasis. In our first journal club, we reviewed how infrequently single fraction treatment is used. Many have had reservation about treating the spine in particular. On Sunday January 17th, we will discuss a retrospective study from Dana-Farber Cancer Institute on palliative radiation for uncomplicated spine metastases:


Adverse Outcomes After Palliative Radiation Therapy for Uncomplicated Spine Metastases: Role of Spinal Instability and Single-Fraction Radiation Therapy. Int J Radiat Oncol Biol Phys 2015;93:373-381


The lead author, Dr. Tai-Chung Lam, will join us to discuss at the live journal club Sunday January 17th at 8-9 PM Central Standard Time. We will focus on differences in the incidence of serious adverse events (SAEs) affecting the treated spine after palliative radiation, the endpoint evaluated in this study. We will cover the following topics during that hour:


T1a.  What is the role of radiation to palliate spinal metastases?

T1b.  What is the current controversy over using single vs. multiple fractions (treatments) for the spine?

T2.  What is the aim of this study, and how was it designed to address that aim?

T3.  How do this study’s findings fit into the existing literature on radiation outcomes for bone metastases?

T4.  What do the study results suggest for clinical practice and future research on bone metastases?


Open discussion and chat for the journal club starts before the live hour with Dr. Lam at 6 AM Central Standard Time.

  • Here is the overview of how to participate
  • Here is Twitter 101 for chat participation
  • Read our disclaimer for ways to keep it rewarding and professional. If you’re not ready, just lurk and tune into the conversation.


Thanks to Katherine Bennett, the article is freely available until Monday 1/18.


Any suggestions? Leave a comment or tweet us at @Rad_Nation. And please join us next week!

radiation nation
Radiation Nation is dedicated to a collaborative approach to sharing for all involved in the use of radiation medicine.
© 2023 Radiation Nation. All rights reserved.