Chemotherapy with Radiation for Low Grade Glioma

For our June #radonc journal club we will discuss the role of chemotherapy in low grade glioma, a specific type of brain tumor. Temozolomide became standard with radiation for glioblastoma in the mid-2000s. Does chemotherapy improve outcomes in less aggressive gliomas? We will review the long-term results of randomized clinical trial RTOG 98-02.

Our article is:

Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma. New Engl J Med 2016;374:1344-1355.

The article is free for download, thanks to NRG Oncology and the New England Journal of Medicine. For the protocol and supplementary materials, click here.

The lead and senior authors, Dr Jan Buckner of Mayo Clinic and Dr. Walter Curran of Emory Winship Cancer Center, will join us to discuss at the live journal club Sunday June 19th at 11AM- 12PM Central Standard Time. We will focus on the following topics:

T1.  What is the role of nonsurgical therapy for low grade glioma?

T2.   What were the aim and methods of this study?

T3.  What were the results, and how do they fit into current standards for treatment delivery?

T4.  What are the key questions for future research on postoperative treatment of low grade glioma?

We will start open chat 6 AM CST Saturday June 18th to include global participation.

• Here are guidelines on how to sign up and participate
• Read our disclaimer for ways to keep it rewarding and professional. If you’re not ready, just lurk and tune into the conversation.

Any suggestions? Leave a comment or tweet us at @Rad_Nation. And please join us this weekend!